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04634nam a22005415i 4500 |
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978-3-030-33668-4 |
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DE-He213 |
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20211012172457.0 |
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cr nn 008mamaa |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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200424s2020 sz | s |||| 0|eng d |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER |
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| International Standard Book Number |
9783030336684 |
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978-3-030-33668-4 |
| 024 7# - |
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10.1007/978-3-030-33668-4 |
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doi |
| 050 #4 - LIBRARY OF CONGRESS CALL NUMBER |
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RM1-950 |
| 072 #7 - |
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MMG |
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bicssc |
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MED071000 |
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bisacsh |
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MKG |
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thema |
| 082 04 - |
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| Classification number |
615 |
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23 |
| 245 10 - TITLE STATEMENT |
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| Title |
Lipid Signaling in Human Diseases |
| Statement of responsibility, etc |
edited by Julian Gomez-Cambronero, Michael A. Frohman. |
| 250 ## - EDITION STATEMENT |
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| Edition statement |
1st ed. 2020. |
| 300 ## - PHYSICAL DESCRIPTION |
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| Extent |
XIV, 336 p. 50 illus., 30 illus. in color. |
| Other physical details |
online resource. |
| 505 0# - |
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| Formatted contents note |
Part 1. New Roles for Sphingolipid Signaling and Cell Function -- 1. Role of Sphingosine Kinase 1 and Sphingosine-1-Phosphate Axis in Hepatocellular Carcinoma -- 2. Exploring the Therapeutic Landscape of Sphingomyelinases -- 3. Sphingosine kinases as druggable targets -- Part 2. Phospholipase D and Mitogen Phosphatidic Acid in Human Disease -- 4. Prospects for PLD inhibition in cancer and thrombotic disease -- 5. Phospholipase D and the Mitogen Phosphatidic Acid in Human Disease: Inhibitors of PLD at the Crossroads of Phospholipid Biology and Cancer -- 6. Role of Phospholipase D-Derived Phosphatidic Acid in Regulated Exocytosis and Neurological Disease -- Part 3. Lipid Kinases and Novel Regulatory Pathways -- 7. Diacylglycerol Kinase Malfunction in Human Disease and the Search for Specific Inhibitors -- 8. Functions of Nuclear Polyphosphoinositides -- Part 4. Bioactive Lipids in Health and Disease -- 9. Platelet-Activating Factor as an Effector for Environmental Stressors -- 10. Phospholipase D and Choline Metabolism -- Part 5- Lipids and Membrane Microdomains -- 11. Regulation of Inositol Biosynthesis: Balancing Health and Pathophysiology -- 12. Lipids and Membrane Microdomains: The Glycerolipid and Alkylphosphocholine Class of Cancer Chemotherapeutic Drugs -- Part 6. Nuclear Trafficking of Lipids -- 13. Inositide-Dependent Nuclear Signalling in Health and Disease -- 14. Lipids in Exosome Biology. |
| 650 #0 - |
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| Topical term or geographic name as entry element |
Pharmacology. |
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| Topical term or geographic name as entry element |
Cancer research. |
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| Topical term or geographic name as entry element |
Medical biochemistry. |
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| Topical term or geographic name as entry element |
Pharmacology/Toxicology. |
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| Topical term or geographic name as entry element |
Cancer Research. |
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| Topical term or geographic name as entry element |
Medical Biochemistry. |
| 700 1# - |
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| Personal name |
Gomez-Cambronero, Julian. |
| Relator term |
editor. |
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| Personal name |
Frohman, Michael A. |
| Relator term |
editor. |
| 710 2# - |
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| Corporate name or jurisdiction name as entry element |
SpringerLink (Online service) |
| 856 40 - |
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| Uniform Resource Identifier |
https://doi.org/10.1007/978-3-030-33668-4 |
| 245 10 - TITLE STATEMENT |
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[electronic resource] / |
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Cham : |
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Springer International Publishing : |
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Imprint: Springer, |
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2020. |
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text |
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txt |
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rdacontent |
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computer |
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c |
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rdamedia |
| 338 ## - |
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online resource |
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cr |
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rdacarrier |
| 347 ## - |
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text file |
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PDF |
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rda |
| 490 1# - |
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Handbook of Experimental Pharmacology, |
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1865-0325 ; |
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259 |
| 520 ## - |
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Lipids are an integral part of cell membrane architecture, are intermediaries in cell metabolism, and are involved in transmitting cell signals from hormones, growth factors and nutrients. A number of lipases and phospholipases, lipid kinases, lipid phosphatases, sphingosine kinases, and their reaction products have been implicated in fundamental cellular processes including cell proliferation, division and migration. These enzymes and their products underlie the molecular mechanisms of numerous human diseases, in particular metabolic disease (diabetes), cancer, neurodegenerative disease and cardiovascular disease. Over the last decade, studies have advanced to the point that a number of inhibitors for these enzymes have been developed to attempt to ameliorate these conditions; some of the inhibitors are currently in human clinical trial. The need for this book is to review the current status of this field and the prospect for the inhibitors to be clinically important. . |
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https://scigraph.springernature.com/ontologies/product-market-codes/B21007 |
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https://scigraph.springernature.com/ontologies/product-market-codes/B11001 |
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https://scigraph.springernature.com/ontologies/product-market-codes/H35005 |
| 700 1# - |
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edt |
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http://id.loc.gov/vocabulary/relators/edt |
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edt |
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http://id.loc.gov/vocabulary/relators/edt |
| 773 0# - |
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Springer Nature eBook |
| 776 08 - |
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Printed edition: |
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9783030336677 |
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Printed edition: |
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9783030336691 |
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Printed edition: |
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9783030336707 |
| 830 #0 - |
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Handbook of Experimental Pharmacology, |
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1865-0325 ; |
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259 |
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ZDB-2-SBL |
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ZDB-2-SXB |
| 950 ## - |
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Biomedical and Life Sciences (SpringerNature-11642) |
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Biomedical and Life Sciences (R0) (SpringerNature-43708) |
