Molecular, Genetic, and Nutritional Aspects of Major and Trace Minerals.

Molecular, Genetic, and Nutritional Aspects of Major and Trace Minerals is a unique reference that provides a complete overview of the non-vitamin micronutrients, including calcium, copper, iodine, iron, magnesium, manganese, molybdenum, phosphorus, potassium, selenium, sodium, and zinc. In addition, the book covers the nutritional and toxicological properties of nonessential minerals chromium, fluoride and boron, and silicon and vanadium, as well as ultra-trace minerals and those with no established dietary requirement for humans. Users will find in-depth chapters on each essential mineral and mineral metabolism, along with discussions of dietary recommendations in the United States and around the world. Presents the only scientific reference to cover all of the nutritionally relevant essential major and trace minerals Provides a broad introductory chapter on each mineral to give readers valuable background and context Clarifies the cellular and molecular aspects of each mineral and its genetic and genomic aspects Includes coverage of all nutritionally relevant minerals--essential major trace minerals and ultra-trace minerals Underscores the important interactions between minerals so readers learn how metabolism of one mineral influences another.

Vendor-supplied metadata.

Front Cover; Molecular, Genetic, and Nutritional Aspects of Major and Trace Minerals; Molecular, Genetic, and Nutritional Aspects of Major and Trace Minerals; Copyright; Contents; List of Contributors; Series Preface; I -- Calcium; 1 -- Calcium-Sensing Receptor Polymorphisms and Human Disease; INTRODUCTION; Calcium-Sensing Receptor in the Parathyroid Glands; Calcium-Sensing Receptor in the Kidney; Calcium-Sensing Receptor in Bones; CALCIUM-SENSING RECEPTOR GENE POLYMORPHISMS AND CALCIUM-PHOSPHATE HOMEOSTASIS; CALCIUM-SENSING RECEPTOR GENE POLYMORPHISMS AND DISORDERS OF THE PARATHYROID GLANDS.

CALCIUM-SENSING RECEPTOR GENE POLYMORPHISMS AND DISORDERS OF THE KIDNEYCALCIUM-SENSING RECEPTOR GENE POLYMORPHISMS AND BONE MINERAL DENSITY; CONCLUSIONS; SUMMARY POINTS; KEY FACTS; MINI DICTIONARY OF TERMS; REFERENCES; 2 -- Molecular Aspects of the Calcium-Sensing Receptor and Calcium Homeostasis; INTRODUCTION; STRUCTURAL COMPONENTS OF THE CALCIUM-SENSING RECEPTOR; CALCIUM-SENSING RECEPTOR FUNCTION IN THE PARATHYROID GLAND; CALCIUM-SENSING RECEPTOR FUNCTION IN BONE; CALCIUM-SENSING RECEPTOR FUNCTION IN THE KIDNEY.

PATHOPHYSIOLOGICAL DISORDERS OF THE KIDNEY AND CALCIUM-SENSING RECEPTOR MODULATIONCALCIUM-SENSING RECEPTOR FUNCTION IN THE GASTROINTESTINAL SYSTEM; CALCIUM-SENSING RECEPTOR FUNCTION IN THE SKIN; CONCLUSION; REFERENCES; 3 -- New Developments in Our Understanding of the Regulation of Calcium Homeostasis by Vitamin D; INTRODUCTION; BIOACTIVATION OF VITAMIN D; REGULATION OF VITAMIN D METABOLISM; NEW INSIGHTS INTO MECHANISMS INVOLVED IN THE EFFECTS OF 1,25(OH)2D3 IN INTESTINE, KIDNEY, AND BONE; Intestine; Kidney; Bone; GENOMIC MECHANISM OF 1,25-DIHYDROXYVITAMIN D3 ACTION.

Adipocyte Fat MetabolismEndoplasmic Reticulum Stress and Inflammation; Novel Adipose-Derived Mediators; Insulin Signaling; CONCLUSION; REFERENCES; 5 -- Calcium: Basic Nutritional Aspects; INTRODUCTION; Functions of Calcium; Calcium Homeostasis, Vitamin D, and Parathyroid Hormone; Dietary Calcium Requirements; Skeletal Health; Bone Density; Fractures; Falls; Cardiovascular Disease; Preeclampsia and Hypertension in Pregnancy; Cancer; Calcium and the Kidney; Renal Stones; Mortality; Source of Calcium: Does It Matter?; Recommendations for Dietary Calcium Intakes; Calcium Intakes.