Studies in natural products chemistry. Volume 50 / edited by Atta-ur-Rahman.

Includes index.

Online resource; title from PDF title page (ScienceDirect, viewed October 6, 2016).

Includes bibliographical references and index.

Front Cover; Studies in Natural Products Chemistry; Studies in Natural Products Chemistry; Copyright; Contents; Contributors; Foreword; Preface; 1 -- Synthesis and Structure-Activity Relations in Allylsulfide and Isothiocyanate Compounds From Garlic and Broccoli Against In Vitro Cancer Cell Growth; BACKGROUND; GARLIC; THE CYTOTOXICITY OF GARLIC/ LLYLSULFUR COMPOUNDS IN/ ANCER CELLS; Garlic Allylsulfur Compounds/ s Glutathione Mimics; The Role of Glutathione in/ he Cell; Garlic Allylsulfur Compounds/ nd the GSH:GSSG Ratio; Posttranslational Modification of Proteins by S-Glutathionylation.

S-Glutathionylation in Cell SignalingSYNTHETIC ROUTES TO GARLIC/ LLYLSULFUR COMPOUNDS AND THEIR DERIVATIVES; The Biosynthesis of Allicin in/ he Plant; Polysulfanes; Dithiins; Ajoenes; STRUCTURE-ACTIVITY RELATIONS OF/ ARLIC ALLYLSULFIDES AGAINST IN/ ITRO CANCER CELL GROWTH; BROCCOLI; THE CYTOTOXICITY OF BROCCOLI ISOTHIOCYANATES IN CANCER CELLS; SYNTHETIC ROUTES TO BROCCOLI ISOTHIOCYANATES AND THEIR/ ERIVATIVES; The Biosynthesis of/ lucosinolates in the Plant; Racemic Sulforaphane/ ynthesis; Enantioselective Sulforaphane Synthesis; Sulforaphane-Isotopically/ abeled Synthesis.

The Chemical Reactivity of Isothiocyanates in Cancer CellsSTRUCTURE-ACTIVITY RELATIONS OF ISOTHIOCYANATES AGAINST IN VITRO CANCER CELL GROWTH; Bifunctional Sulforaphane/ imics; Monofunctional/ sothiocyanates; COMMONALITY IN THE ANTICANCER MECHANISMS OF ISOTHIOCYANATES/ ND POLYSULFIDES IN CANCER CELLS; CONCLUSION; REFERENCES; 2 -- Natural Products as Lead Protein Kinase C Modulators for Cancer Therapy; INTRODUCTION; ISOFORMS OF PROTEIN KINASE C FAMILY; Structure and Mechanisms of Regulation; Protein Kinase C and Carcinogenesis; PHORBOL ESTERS; BRYOSTATINS; STAUROSPORINE ANALOGS.

INGENENE DITERPENESMISCELLANEOUS AND PROMISING AGENTS; Daphnane Diterpenes; Abietane Diterpenoids; Phenolic Compounds; CONCLUDING REMARKS; ACKNOWLEDGMENTS; REFERENCES; 3 -- Plant-Derived Prooxidants as Potential Anticancer Therapeutics; INTRODUCTION; TYPES OF REACTIVE OXYGEN SPECIES CAUSING OXIDATIVE STRESS; SOURCES OF CELLULAR REACTIVE/ XYGEN SPECIES; PHYSIOLOGICAL ROLE(S) OF REACTIVE OXYGEN SPECIES; ATTENUATION OF OXIDATIVE STRESS BY ANTIOXIDANTS; MODULATION OF REACTIVE OXYGEN SPECIES AND THE PATHOGENESIS/ F CANCERS; PROOXIDANTS AS POTENTIAL ANTICANCER COMPOUNDS; Prooxidant-Induced Apoptosis.

IMPACT OF PROOXIDANTS UPON OXIDATIVE STRESS-RELATED/ IGNALING EVENTSHOW DO PROOXIDANTS REGULATE/ HE SIGNALING PATHWAYS?; Prosurvival Pathways; Phosphatidylinositide/ -Kinase/AKT Signaling Pathways; Redox Factor-1/Thioredoxin Signaling Pathways; Nuclear Factor Erythroid 2-Related Factor 2/ ignaling Pathways; Nuclear Factor/ appa-Light Chain/ nhancer of Activated B/ ell Signaling Pathways; Antisurvival Pathways; Mitogen-Activated/ rotein Kinases Signaling Pathways; Reactive Oxygen Species/ nd DNA Damage/ esponse; CONCLUDING REMARKS; REFERENCES.

4 -- Anticancer and Antineurodegenerative Effects of Ginsenosides.

Natural products in the plant and animal kingdom offer a huge diversity of chemical structures that are the result of biosynthetic processes that have been modulated over the millennia through genetic effects. With the rapid developments in spectroscopic techniques and accompanying advances in high-throughput screening techniques, it has become possible to isolate and then determine the structures and biological activity of natural products rapidly, thus opening up exciting opportunities in the field of new drug development to the pharmaceutical industry. This series covers the synthesis or testing and recording of the medicinal properties of natural products, providing cutting edge accounts of the fascinating developments in the isolation, structure elucidation, synthesis, biosynthesis and pharmacology of a diverse array of bioactive natural products.