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Lipid-based nanocarriers for drug delivery and diagnosis / Muhammad Raza Shah, Muhammad Imran and Shafi Ullah.

By: Shah, Muhammad Raza [author.]Contributor(s): Imran, Muhammad [author.] | Ullah, Shafi [author.]Material type: TextTextSeries: Micro & nano technologiesPublisher: Oxford, United Kingdom : Elsevier, [2017]Copyright date: �2017Description: 1 online resourceContent type: text Media type: computer Carrier type: online resourceISBN: 9780323527309; 0323527302Subject(s): Liposomes | Nanostructures | Liposomes -- pharmacokinetics | Nanostructures -- therapeutic use | Drug Delivery Systems | MEDICAL -- Pharmacology | Liposomes | NanostructuresGenre/Form: Electronic book. | Electronic books.Additional physical formats: Print version:: Lipid-based nanocarriers for drug delivery and diagnosis.DDC classification: 615.7 LOC classification: RS201.L55NLM classification: 2017 G-081 | QU 93Online resources: ScienceDirect | ScienceDirect
Contents:
Front Cover; Lipid-based Nanocarriers for Drug Delivery and Diagnosis; Copyright Page; Contents; Biographies; Preface; 1 Solid lipid nanoparticles; 1.1 Introduction; 1.2 Advantages; 1.3 Structural Composition of Solid Lipid Nanoparticles; 1.3.1 Lipids; 1.3.2 Surfactants; 1.3.3 Other Ingredients Used; 1.4 Incorporation of Drugs in Solid Lipid Nanoparticles; 1.4.1 Homogeneous Matrix Model; 1.4.2 Drug-Enriched Shell Model; 1.4.3 Drug-Enriched Core Model; 1.5 Preparation Techniques of Solid Lipid Nanoparticles; 1.5.1 High-Pressure Homogenization; 1.5.1.1 Hot homogenization.
1.5.1.2 Cold homogenization1.5.2 Precipitation From Homogeneous Systems; 1.5.2.1 Precipitation from warm microemulsions; 1.5.2.2 Precipitation from water-miscible organic solvents; 1.5.3 Microwave-Assisted Microemulsion Technique; 1.5.4 Solvent Emulsification-Evaporation Method; 1.5.5 Double Emulsion-Based Method; 1.5.6 Emulsification-Diffusion Technique; 1.5.7 Solvent Displacement/Injection Method; 1.5.8 High Shear Homogenization/Ultrasound Method; 1.5.9 Membrane Contactor Method; 1.5.10 Solid Lipid Nanoparticle Preparation by Using Supercritical Fluid; 1.5.11 Coacervation Method.
1.5.12 Phase Inversion Temperature Method1.6 Sterilization; 1.6.1 Moist Heat Sterilization; 1.6.2 Gamma-Radiation; 1.6.3 Filtration; 1.7 Lyophilization and Spray Drying of Solid Lipid Nanoparticles; 1.8 Characterization; 1.8.1 Particle Size and Size Distribution; 1.8.2 Particle Shape and Morphology; 1.8.3 Zeta Potential; 1.8.4 Polymorphism and Crystallinity of Lipids; 1.8.5 Functionality Assay; 1.9 Drug Release From Solid Lipid Nanoparticles; 1.10 Problems With Solid Lipid Nanoparticles Preparation and Performance; 1.10.1 High Pressure-Induced Drug Degradation; 1.10.2 Gelation Phenomena.
1.10.3 Coexistence of Several Colloidal Species1.11 Solid Lipid Nanoparticles Application; 1.11.1 Improved Bioavailability; 1.11.2 Controlled Release; 1.11.3 Passive Targeting; 1.11.4 Active Targeting; References; Further Reading; 2 Nanostructured lipid carriers; 2.1 Introduction; 2.2 Distinct Advantages of Nanostructured Lipid Carriers; 2.2.1 Enhanced Drug Loading Capacity; 2.2.2 Modulation of Drug Release Profile; 2.2.3 Long-Term Stability Drug During Storage; 2.2.4 Decrease Surfactants Concentration Use; 2.3 Types of Nanostructured Lipid Carriers; 2.3.1 Imperfect Type.
2.3.2 "Amorphous" Type2.3.3 "Multiple" Type; 2.4 Nanostructured Lipid Carriers Drug Incorporation Models; 2.5 Nanostructured Lipid Carriers Formulation; 2.5.1 Composition; 2.5.2 Preparation Methods; 2.5.2.1 High-pressure homogenization; 2.5.2.2 Ultrasonication; 2.5.2.3 Solvent diffusion method; 2.6 Structural Investigations of Nanostructured Lipid Carriers; 2.6.1 Nanostructured Lipid Carriers Morphology; 2.6.2 Particle Size; 2.6.3 Zeta Potential; 2.6.4 Differential Scanning Calorimetry; 2.6.5 X-Ray Diffraction; 2.6.6 Magnetic Resonance Investigation; 2.6.7 Raman and IR Spectroscopy.
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Ebooks Ebooks Mysore University Main Library
Not for loan EBKELV950

Includes bibliographical references and index.

Vendor-supplied metadata.

Front Cover; Lipid-based Nanocarriers for Drug Delivery and Diagnosis; Copyright Page; Contents; Biographies; Preface; 1 Solid lipid nanoparticles; 1.1 Introduction; 1.2 Advantages; 1.3 Structural Composition of Solid Lipid Nanoparticles; 1.3.1 Lipids; 1.3.2 Surfactants; 1.3.3 Other Ingredients Used; 1.4 Incorporation of Drugs in Solid Lipid Nanoparticles; 1.4.1 Homogeneous Matrix Model; 1.4.2 Drug-Enriched Shell Model; 1.4.3 Drug-Enriched Core Model; 1.5 Preparation Techniques of Solid Lipid Nanoparticles; 1.5.1 High-Pressure Homogenization; 1.5.1.1 Hot homogenization.

1.5.1.2 Cold homogenization1.5.2 Precipitation From Homogeneous Systems; 1.5.2.1 Precipitation from warm microemulsions; 1.5.2.2 Precipitation from water-miscible organic solvents; 1.5.3 Microwave-Assisted Microemulsion Technique; 1.5.4 Solvent Emulsification-Evaporation Method; 1.5.5 Double Emulsion-Based Method; 1.5.6 Emulsification-Diffusion Technique; 1.5.7 Solvent Displacement/Injection Method; 1.5.8 High Shear Homogenization/Ultrasound Method; 1.5.9 Membrane Contactor Method; 1.5.10 Solid Lipid Nanoparticle Preparation by Using Supercritical Fluid; 1.5.11 Coacervation Method.

1.5.12 Phase Inversion Temperature Method1.6 Sterilization; 1.6.1 Moist Heat Sterilization; 1.6.2 Gamma-Radiation; 1.6.3 Filtration; 1.7 Lyophilization and Spray Drying of Solid Lipid Nanoparticles; 1.8 Characterization; 1.8.1 Particle Size and Size Distribution; 1.8.2 Particle Shape and Morphology; 1.8.3 Zeta Potential; 1.8.4 Polymorphism and Crystallinity of Lipids; 1.8.5 Functionality Assay; 1.9 Drug Release From Solid Lipid Nanoparticles; 1.10 Problems With Solid Lipid Nanoparticles Preparation and Performance; 1.10.1 High Pressure-Induced Drug Degradation; 1.10.2 Gelation Phenomena.

1.10.3 Coexistence of Several Colloidal Species1.11 Solid Lipid Nanoparticles Application; 1.11.1 Improved Bioavailability; 1.11.2 Controlled Release; 1.11.3 Passive Targeting; 1.11.4 Active Targeting; References; Further Reading; 2 Nanostructured lipid carriers; 2.1 Introduction; 2.2 Distinct Advantages of Nanostructured Lipid Carriers; 2.2.1 Enhanced Drug Loading Capacity; 2.2.2 Modulation of Drug Release Profile; 2.2.3 Long-Term Stability Drug During Storage; 2.2.4 Decrease Surfactants Concentration Use; 2.3 Types of Nanostructured Lipid Carriers; 2.3.1 Imperfect Type.

2.3.2 "Amorphous" Type2.3.3 "Multiple" Type; 2.4 Nanostructured Lipid Carriers Drug Incorporation Models; 2.5 Nanostructured Lipid Carriers Formulation; 2.5.1 Composition; 2.5.2 Preparation Methods; 2.5.2.1 High-pressure homogenization; 2.5.2.2 Ultrasonication; 2.5.2.3 Solvent diffusion method; 2.6 Structural Investigations of Nanostructured Lipid Carriers; 2.6.1 Nanostructured Lipid Carriers Morphology; 2.6.2 Particle Size; 2.6.3 Zeta Potential; 2.6.4 Differential Scanning Calorimetry; 2.6.5 X-Ray Diffraction; 2.6.6 Magnetic Resonance Investigation; 2.6.7 Raman and IR Spectroscopy.

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