Transmembrane Dynamics of Lipids / edited by Philippe F. Devaux, Andreas Herrmann.

Frontmatter -- Assessing Transmembrane Movement and Asymmetry of Lipids. Methods for the Determination of Lipid Transmembrane Distribution and Movement in Biological Membranes / Philippe F Devaux, Andreas Herrmann -- Detection and Measurement of Unlabeled Lipid Transmembrane Movement / Iv̀n L̤pez-Montero, Marisela V̌lez, Philippe F Devaux -- Lipid Asymmetry in Cell Membranes. New Insights in Membrane Lipid Asymmetry in Animal and Plant Cells / Alain Zachowski -- Sphingolipid Asymmetry and Transmembrane Translocation in Mammalian Cells / Gerrit van Meer, Sylvia Neumann, Per Haberkant -- Transbilayer Movement and Distribution of Cholesterol / Peter Muller, Anna Pia Plazzo, Andreas Herrmann -- Energy-Independent Protein-Mediated Transmembrane Movement of Lipids. Phospholipid Flip-Flop in Biogenic Membranes / Anant K Menon, Andreas Herrmann -- Phospholipid Scramblase: When Phospholipid Asymmetry Goes Away / Edouard M Bevers, Patrick L Williamson -- Energy-Dependent Lipid Transport Across Membranes. Flip or Flop: Mechanism and (Patho)Physiology of P-ATPase-Catalyzed Lipid Transport / Patricia M Verhulst, Joost C M Holthuis, Thomas G Pomorski -- Coupling Drs2p to Phospholipid Translocation, Membrane Asymmetry, and Vesicle Budding / Xiaoming Zhou, Paramasivam Natarajan, Baby-Periyanayaki Muthusamy, Todd R Graham, Ke Liu -- Substrate Specificity of the Aminophospholipid Flippase / Shelley M Cook, David L Daleke -- The Flippase Delusion? / Naomi L Pollock, Petra H M Niesten, Richard Callaghan -- Relevance of Lipid Transmembrane Distribution for Membrane Properties and Processes. Membrane Lipid Asymmetry and Permeability to Drugs: A Matter of Size / Adam Blanchard, Cyril Rauch -- Endocytosis and Lipid Asymmetry / Nina Ohlwein, Andreas Herrmann, Philippe F Devaux -- Apoptosis and Diseases: Consequences of Disruption to Lipid Transmembrane Asymmetry. Membrane Lipid Asymmetry in Aging and Apoptosis / Krishnakumar Balasubramanian, Alan J Schroit -- Phosphatidylserine Exposure in Hemoglobinopathies / Frans A Kuypers, Eric Soupene -- Scott Syndrome: More Than a Hereditary Defect of Plasma Membrane Remodeling / Florence Toti, Jean-Marie Freyssinet -- ABCA1, Tangier Disease, and Lipid Flopping / Ana Zarubica, Giovanna Chimini -- Index.

Print version.

Includes bibliographical references and index.

"As the building blocks of biological membranes, lipids have a very complex set of behaviors that, when defective, can be a major distributor of diseases, including cancer. As the only book to date devoted entirely to lipids in membranes, Membrane Asymmetry and Transmembrane Motion of Lipids enlists leading research groups to present up-to-date quantitative data on the formation, stability and biological consequences of the asymmetrical organization of lipids in cell membranes. With an impressive amount of data, this book explores exciting new discoveries that show promising potential for future study"-- Provided by publisher.

"The multi-authored book contains modern information on all major aspects related to the formation, stability and biological consequences of the asymmetrical organization of lipids in cell membranes. It introduces the phenomenon of membrane asymmetry, describes transmembrane distribution of lipids in biological membranes, represents methods for the measurement of the transmembrane lipid motion, emphasizes the role of flippases, discusses biological functions associated with lipid asymmetry and outlines correlations between lipid asymmetry and human diseases such as thrombosis, cancer, and apoptosis"-- Provided by publisher.