Proteomics of biological systems : protein phosphorylation using Mass spectrometry techniques / Bryan M. Ham.
Material type:
TextPublisher number: EB00062742 | Recorded BooksPublisher: Hoboken, N.J. : John Wiley & Sons, [2012]Copyright date: ©2012Description: 1 online resource (xxiii, 350 pages) : illustrationsContent type: text Media type: computer Carrier type: online resourceISBN: 9781118137048; 1118137043; 9781118137017; 1118137019; 9781118137031; 1118137035; 1283282852; 9781283282857Subject(s): Proteomics -- Methodology | Phosphorylation -- Research -- Methodology | Phosphoproteins -- Synthesis | Mass spectrometry | SCIENCE -- Life Sciences -- Biochemistry | ScienceGenre/Form: Electronic resource. | Electronic books. | Electronic books.Additional physical formats: Print version:: Proteomics of Biological Systems.DDC classification: 572/.62 LOC classification: QP519.9.M3 | H367 2012Online resources: Wiley Online Library | Item type | Current library | Call number | Status | Date due | Barcode |
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Ebooks
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Mysore University Main Library | Not for loan | EBJW1184 |
Posttranslational Modification (PTM) of Proteins -- Glycosylation of Proteins -- Sulfation of Proteins as Posttranslational Modification -- Eukaryote PTM as Phosphorylation: Normal State Studies -- Eukaryote PTM as Phosphorylation: Perturbed State Studies -- Prokaryotic Phosphorylation of Serine, Threonine, and Tyrosine -- Prokaryotic Phosphorylation of Histidine -- Appendix I: Atomic Weights and Isotopic Compositions -- Appendix II: Periodic Table of the Elements -- Appendix III: Fundamental Physical Constants.
Phosphorylation is the addition of a phosphate (PO₄) group to a protein or other organic molecule. Phosphorylation activates or deactivates many protein enzymes, causing or preventing the mechanisms of diseases such as cancer and diabetes. This book shows how to use mass spectrometry to determine whether or not a protein has been correctly modified by the addition of a phosphate group. It also provides a combination of detailed, step-by-step methodology for phosphoproteomic sample preparation, mass spectral instrumental analysis, and data interpretation approaches. Furthermore, it includes the use of bioinformatic Internet tools such as the Blast2GO gene ontology (GO) tool, used to help understand and interpret complex data collected in these studies.
Includes bibliographical references and index.
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