Micronutrients in health and disease / Kedar N. Prasad.

Cover; Half Title; Title Page; Copyright Page; Table of Contents; Preface; Acknowledgments; Author; Chapter 1: Basic Facts about Micronutrients; Introduction; Evolution of the Antioxidant System; History of the Discovery of Micronutrients; Sources and Forms of Vitamins; Solubility of Micronutrients; Distribution of Antioxidants in the Body; Storage of Antioxidants; Can Antioxidants Be Destroyed during Cooking?; Absorption of Antioxidants and Its Significance; Functions of Individual Antioxidants; Antioxidant Defense Systems; Antioxidant Enzymes; Dietary Antioxidants; Endogenous Antioxidants

Known Functions of AntioxidantsCurrent Controversies about Antioxidants; Misuse of Antioxidants in Clinical Studies; Conclusions; References; Chapter 2: Basic Facts about Oxidative Stress, Inflammation, and the Immune System; Introduction; Oxidative Stress; What Are Free Radicals?; Types of Free Radicals; Formation of Free Radicals Derived from Oxygen and Nitrogen; Oxidation and Reduction Processes; What Is Inflammation?; Types of Inflammatory Reactions; Products of Inflammatory Reactions; Cytokines; Complement Proteins; Arachidonic Acid (AA) Metabolites

Endothelial/Leukocyte Adhesion MoleculesImmune System; What Is the Immune System?; Innate Immunity; Adaptive Immunity; Conclusions; References; Chapter 3: Scientific Rationale of Current Trends in Clinical Studies of Micronutrients; Introduction; Levels of Oxidative Stress and Chronic Inflammation in High-Risk Populations; High-Risk Populations of Cancer; High-Risk Populations of Coronary Artery Disease (CAD); High-Risk Populations of Alzheimer's Disease (AD) and Parkinson's Disease (PD); Distributions and Function of Antioxidants

Results of Clinical Trials with a Single Antioxidant in High-Risk PopulationsCancer; Coronary Artery Disease (CAD); Alzheimer's Disease (AD) and Parkinson's Disease (PD); Why the Use of a Single Antioxidant Produced Inconsistent Results; Results of Clinical Studies with Multiple Dietary Antioxidants in Cancer; Results of Clinical Studies with Fat and Fiber; Rationale for Using a Mixture of Micronutrients for Reducing the Risk and Progression of Chronic Diseases; Proposed Mixture of Micronutrients for Reducing the Risk and Progression of Chronic Diseases

Proposed Changes in Diet and Lifestyle for Reducing the Risk and Progression of Chronic DiseasesConclusions; References; Chapter 4: Micronutrients in Healthy Aging and Age-Related Decline in Organ Functions; Introduction; Trends of Aging Population; Evidence for Increased Oxidative Stress During Aging; Extracellular Sources for Production of Free Radicals; Cellular Sites of Production of Free Radicals; Oxidative Stress-Induced Age-Related Decline in Organelle Functions; Mitochondrial Dysfunction; Impairment of Proteasome and Lysosomal-Mediated Proteolytic Activities

Growing sentiments against using micronutrient supplements for improving health and preventing disease have created uncertainty in the minds of many health professionals. Following its predecessor, this new edition supports the use of multiple micronutrients combined with proper diet to prove successful in the prevention and management of chronic diseases. It provides basic information on micronutrients, oxidative stress, inflammation, and the immune system. The book goes further to explore use of multiple micronutrients in prevention and treatment of diseases including arthritis, cancer, diabetes, heart diseases, traumatic brain injury, PTSD, prion diseases, and autism spectrum disorder. Key Features Proposes sevidence-based micronutrient supplementation strategies for healthy aging and disease management and prevention. Contains three new chapters on Huntington's Disease, prion diseases, and autism spectrum disorder. All chapters include new studies on etiology, incidence, and mechanisms of several diseases. Discusses role of microRNAs in the initiation and progression for each disease.

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